Apoptosis Inducing Factor

A flavoprotein that functions as a powerful antioxidant in the MITOCHONDRIA and promotes APOPTOSIS when released from the mitochondria. In mammalian cells AIF is released in response to pro-apoptotic protein members of the bcl-2 protein family. It translocates to the CELL NUCLEUS and binds DNA to stimulate CASPASE-independent CHROMATIN condensation.

Also Known As:

AIF Apoptosis Regulatory Protein; Apoptosis-Inducing Factor; Mitochondrial Apoptosis-Inducing Factor; Apoptosis-Inducing Factor, Mitochondrial; Mitochondrial Apoptosis Inducing Factor

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Oxidoreductases: 13899
    - NADPH Oxidoreductases NADH
      - Apoptosis Inducing Factor: 490
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Carrier Proteins: 13306
    - Poly-ADP-Ribose Binding Proteins
      - Apoptosis Inducing Factor: 490
  - Nuclear Proteins: 2740
    - Poly-ADP-Ribose Binding Proteins
      - Apoptosis Inducing Factor: 490
  - Flavoproteins: 240
    - Apoptosis Inducing Factor: 490
  - Intracellular Signaling Peptides and Proteins: 32
    - Apoptosis Regulatory Proteins: 2581
      - Apoptosis Inducing Factor: 490
- Peptides: 84029
  - Intracellular Signaling Peptides and Proteins: 32
    - Apoptosis Regulatory Proteins: 2581
      - Apoptosis Inducing Factor: 490

Jan Michael A Lerot Selected Research

Jan Michael A Lerot Research Topics

Disease

Drug/Important Bio-Agent (IBA)